Poster 21: Hypoglycaemia on oral glucose tolerance test in pregnancy - is it significant?

Mung SM, Hussain HAHA, Thu WMT, Mashamba CJM and Jude EJ
Tameside General Hospital

Background: Hypoglycaemia during OGTT has been linked with poor pregnancy outcome but results are conflicting.

Method: 75-grams 2-hour OGTT from 2017-2018 of 159 pregnant women were analysed. Women were divided into following groups: normoglycemia (Fasting Blood Glucose 4-5.5 mmol/L and 2-hour OGTT 4-7.7 mmol/L), GDM (FBG ≥ 5.6 mmol/litre or 2-hour OGTT ≥ 7.8 mmol/L), hypoglycaemia (2 hr-OGTT 3-3.9 mmol/L) and clinically significant hypoglycaemia CSH (2 hr-OGTT <3 mmol/L). Endpoints were Maternal BMI, foetal body weight (FBW), mode of delivery and admission to Neonatal Intensive Care Unit (NICU).

Results: Maternal BMI was significantly lower in the hypoglycaemia group (p=0.04) but not in those with CSH (p=0.89). FBW was non-significantly higher in those with CSH (p=0.69).

Mode of delivery was not significantly different between normoglycemia and the 2 hypoglycaemia groups (p=0.74 for hypoglycaemia and p=0.82 for CSH). The GDM group was significantly more likely to require Emergency C-section (p=0.03).

Neonates born to the hypoglycaemia group were more likely to require NICU admission but this was non-significant (p=0.3). None of the neonates born to the CSH group required admission to NICU (n=16).

Discussion: Neonates born to mothers who had hypoglycaemia on 2-hour OGTT were more likely to require admission to neonatal ICU; however, this finding was statistically non-significant. Furthermore, their mode of delivery was non-significantly different to the normoglycemic group. Currently there is insufficient evidence to advocate intense monitoring or treatment in pregnant women who develop hypoglycaemia on oral glucose tolerance test (OGTT).

Clinical taxonomy: 
Type 1 diabetes mellitus
Type 2 diabetes mellitus
Resource taxonomy: 
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