Once-Weekly Semaglutide 2.4 mg Improved Glucose Metabolism and Prediabetes in Adults with Overweight/Obesity in the STEP 1 Trial

Mimi Chen¹; Leigh Perreault²; Melanie Davies³; Juan P Frias⁴; Peter Nørkjaer Laursen⁵; Ildiko Lingvay⁶; Sriram Machineni⁷; Anette Varbo⁵; John PH Wilding⁸; Signe Olrik Rytter Wallenstein⁵; Carel W le Roux⁹

1 Thomas Addison Unit, St. George’s University Hospitals NHS Foundation Trust & St. George’s University of London, London, UK
2 Department of Medicine/Division of Endocrinology, Metabolism and Diabetes, University of Colorado Anschutz Medical Campus, Aurora, CO, USA
3 Diabetes Research Centre, University of Leicester, Leicester, UK; NIHR Leicester Biomedical Research Centre, Leicester, UK
4 National Research Institute, Los Angeles, CA, USA
5 Novo Nordisk A/S, Søborg, Denmark; 6Departments of Internal Medicine/Endocrinology and Population and Data Sciences, University of Texas Southwestern Medical Center, Dallas, TX, USA
7 Division of Endocrinology and Metabolism/Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, NC, USA
8 Department of Cardiovascular and Metabolic Medicine, Institute of Life Course and Medical Sciences, University of Liverpool, Liverpool, UK
9 Diabetes Complications Research Centre Conway Institute University College, Dublin, Ireland