SGLT-2 inhibitors in people with type 2 diabetes

An educational resource for health professionals

Umesh Dashora, Dipesh Patel, Dinesh Nagi, Susannah Rowles, Emma Wilmot, Andrew Macklin, Peter Winocour, Ketan Dhatariya

Two of ABCDs core objectives are to ensure the highest quality of care for patients with diabetes and to provide a resource of information not only for our members but also the wider multidisciplinary team and colleagues providing care for people with diabetes.

The rapid evolution of the SGLT-2 inhibitors in joining the pharmacological armamentarium to help manage hyperglycaemia in Type 2 diabetes is to be celebrated however; it can pose some clinical conundrums in terms of which patients to select for this class and how to minimize risks of harm. Over time, there will be increasing clarity as to the best groups of patients who will benefit from these medications; even as this goes to the printers there is further emerging data on the benefits of SGLT 2 inhibitors and quantification of risk. We hope that this document will help pragmatically support those involved in the day to day care of people with type 2 diabetes in the “here and now”, with the aim of maximizing the benefits and minimizing harm.